Effective transcatheter intracoronary delivery of mRNA-lipid nanoparticles targeting the heart.

Messenger RNA (mRNA) has great potential to provide innovative medical solutions in the treatment of heart failure. Although lipid nanoparticles (LNPs) are an established mRNA delivery system, effectively delivering LNPs to the heart remains a significant challenge. Here, we evaluated the efficacy of transcatheter intracoronary (IC) administration compared to intravenous (IV) and intramyocardial (IM) administration in normal and ischemia-reperfusion (I/R) model rabbit hearts using LNPs encapsulating Firefly Luciferase (FLuc) mRNA.

Co-representation breaks down beyond the dyad in UK adults.

Cooperation is so deeply embedded in human psychology that we spontaneously track a partner's task as well as our own when acting in a pair. This automatic 'co-representation' of a partner's mental representation of their task has been argued to be key to the sophisticated social coordination we see in human adults. However, our day-to-day encounters are not limited to one-to-one interactions.

Delayed recognition of mpox on an inpatient psychiatric unit: a case report and investigation.

This report describes a delayed recognition of mpox in a patient admitted to an inpatient psychiatry unit, resulting in potential exposures to staff and patients. We detail the investigation and risk mitigation efforts and emphasize the importance of prompt identification and isolation in congregate healthcare settings to prevent transmission.

MacaqueNet: Advancing comparative behavioural research through large-scale collaboration.

There is a vast and ever-accumulating amount of behavioural data on individually recognised animals, an incredible resource to shed light on the ecological and evolutionary drivers of variation in animal behaviour. Yet, the full potential of such data lies in comparative research across taxa with distinct life histories and ecologies. Substantial challenges impede systematic comparisons, one of which is the lack of persistent, accessible and standardised databases.