Publications by authors named "J M Wal"
Background: Digital adherence technologies (DATs) with associated differentiated care are potential tools to improve tuberculosis (TB) treatment outcomes and reduce associated costs for both patients and healthcare providers. However, the balance between epidemiological and economic benefits remains unclear. Here, we used data from the ASCENT trial to estimate the potential long-term epidemiological and economic impact of DAT interventions in Ethiopia.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the impact of ethnicity on maternal and perinatal outcomes among low-risk women in a midwife-led care setting, focusing on non-Western versus Dutch women.
- A cohort of 977 low-risk pregnant women was analyzed, with key outcomes including gestational age, mode of birth, and birthweight, while controlling for various factors like area deprivation and maternal education.
- Findings revealed that non-Western women had a higher likelihood of specific characteristics such as being multiparous, living in deprived areas, having lower education, and higher BMI, along with more significant challenges in prenatal care and a higher incidence of gestational diabetes compared to their Dutch counterparts.
Article Synopsis
- - Mucosal melanoma (MucM) is a rare and aggressive form of cancer that responds poorly to immune checkpoint inhibition (ICI), especially when compared to cutaneous melanoma (CM).
- - Analysis of 101 MucM tumors revealed lower levels of the immune marker IFN-γ and indicated that head and neck MucM had more immune cells and higher IFN-γ levels than MucM from other body sites.
- - The study found that immune features differed across tumor locations, with immune-infiltrated tumors showing potential resistance mechanisms to ICI, highlighting the need for personalized treatment approaches for MucM.
Photoswitchable molecules that undergo nanoscopic changes upon photoisomerisation can be harnessed to control macroscopic properties such as colour, solubility, shape, and motion of the systems they are incorporated into. These molecules find applications in various fields of chemistry, physics, biology, and materials science. Until recently, research efforts have focused on the design of efficient photoswitches responsive to low-energy (red or near-infrared) irradiation, which however may compromise other molecular properties such as thermal stability and robustness.
View Article and Find Full Text PDFThere is evidence from both behavior and brain activity that the way information is structured, through the use of focus, can up-regulate processing of focused constituents, likely to give prominence to the relevant aspects of the input. This is hypothesized to be universal, regardless of the different ways in which languages encode focus. In order to test this universalist hypothesis, we need to go beyond the more familiar linguistic strategies for marking focus, such as by means of intonation or specific syntactic structures (e.
View Article and Find Full Text PDF