Publications by authors named "J M W van den Ouweland"
Article Synopsis
- Haematology patients experiencing high-risk neutropenia are susceptible to bloodstream infections linked to mucosal barrier injuries, particularly during episodes of fever.
- A study involving 416 neutropenic haematology patients identified risk factors for these infections, noting that certain conditions like low MASCC scores and specific fungal colonizations significantly increased risk.
- Findings revealed that while low citrulline levels at fever onset correlated with candidaemia, they did not indicate the likelihood of bacterial infections; moreover, quinolone antibiotics appeared beneficial.
Article Synopsis
- High levels of a specific protein related to vitamin K deficiency were linked to worse outcomes in COVID-19 patients, indicating the potential importance of vitamin K in managing the disease.
- A clinical trial was conducted with 40 hospitalized patients, where half received vitamin K2 supplements and the other half received a placebo, focusing on their impacts on vitamin K status and related health markers.
- Results showed that vitamin K2 supplementation was safe and significantly improved vitamin K status but did not demonstrate a protective effect against the breakdown of elastic fibers in the body.
Objectives: Current liquid chromatography-tandem mass spectrometry (LC-MS/MS) applications for circulating androgen measurements are technically diverse. Previously, variable results have been reported for testosterone. Data are scarce for androstenedione and absent for dehydroepiandrosterone sulfate (DHEAS).
View Article and Find Full Text PDFBackground: Over the past decade the use of LC-MS/MS has increased significantly in the hospital laboratories. Clinical laboratories have switched from immunoassays to LC-MS/MS methods due to the promise of improvements in sensitivity and specificity, better standardization with often non-commutable international standards, and better between-laboratory comparison. However, it remains unclear whether routine performance of the LC-MS/MS methods have met these expectations.
View Article and Find Full Text PDFObjectives: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) panels that include glucocorticoid-related steroids are increasingly used to characterize and diagnose adrenal cortical diseases. Limited information is currently available about reproducibility of these measurements among laboratories. The aim of the study was to compare LC-MS/MS measurements of corticosterone, 11-deoxycortisol and cortisone at eight European centers and assess the performance after unification of calibration.
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