Effect of salmon calcitonin on femoral bone quality in adult ovariectomized ewes.

The aim of this study was to evaluate the effect of intermittent calcitonin on femoral bone quality in adult ewes from the time of ovariectomy. Six months after the start of the experiment, bone density measurements and mechanical testing (torsion and resonant frequency analysis of the diaphysis and compression of an excised trabecular bone cylinder from the femoral neck) were performed in sham-control and ovariectomized (OVX) ewes treated with placebo or salmon calcitonin (50 or 100 units, 3 times/week). Crystallinity of bone was evaluated by measuring X-ray diffraction line broadening.

Bone changes in 6-mo-old rats after head-down suspension and a reambulation period.

In mature rats experiencing 14-day head-down suspension or 14-day head-down suspension followed by 28-day reambulation, the hindlimb long bones, humerus, and skull were removed for the determination of morphometry and bone mineral content (BMC) and density (BMD) with dual-energy X-ray absorptiometry, dry and ash weights, and calcium content. The bones of the animals in the control groups (killed at days 0, 14, and 42) had their own maturation rate. The body weights of suspended animals were lower than those of the control animals.

Recovery from pamidronate (APD): a two-year study in the dog.

The goal of this study was to find out if bone can recover after long-term administration of bisphosphonate. Disodium pamidronate (APD) was given orally by gavage to mature beagle dogs at doses of 0, 2.5, 12.

Possible nonlinear effects of exercise on bone in male subjects over age 60 years.

We investigated the relationships among bone mass, bone cell activities, and exercise level in 20 healthy 61-77 year old male volunteers divided into three groups according to the time they physically trained per week: nine subjects training less than 3 hr/week, five subjects between 3 and 6 hr/week and six subjects more than 6 hr/week. Physical performance was evaluated by VO2 max (ml min-1 kg-1). After tetracycline double labeling, iliac crest biopsy was obtained from each subject.