Publications by authors named "J M Verkuyl"
Drug-resistant epilepsy patients may benefit from non-pharmacological therapies, such as the ketogenic diet (KD). However, its high fat content poses compliance challenges and metabolic risks. To mitigate this, we developed a novel KD composition with less fat and additional nutrients (citrate, nicotinamide riboside, and omega-3 fatty acids) for ketone-independent neuroprotection.
View Article and Find Full Text PDFThe classic ketogenic diet is an effective treatment option for drug-resistant epilepsy, but its high fat content challenges patient compliance. Optimizing liver ketone production guided by a method comparing substrates for their ketogenic potential may help to reduce the fat content of the diet without loss in ketosis induction. Here, we present a liver cell assay measuring the β-hydroxybutyrate (βHB) yield from fatty acid substrates.
View Article and Find Full Text PDFArticle Synopsis
- Phenylketonuria (PKU) is a metabolic disorder caused by mutations in the PAH gene, leading to high levels of phenylalanine (Phe) that can harm brain development and function.
- The study tested how varying concentrations of Phe affected myelin in different models, finding that high Phe levels did not show toxicity in simple cell cultures but promoted oligodendrocyte maturation.
- However, in more complex brain slice cultures, prolonged exposure to Phe significantly decreased myelin proteins and led to microglial activation, suggesting that high Phe levels can disrupt myelin and trigger neuroinflammation.
The EAT-Lancet reference diet and cognitive function across the life course.
Lancet Planet Health
September 2022
The EAT-Lancet Commission devised a sustainable reference diet with the aim of reducing the incidence of non-communicable diseases and mortality globally while improving food system sustainability. The extent to which the reference diet supports cognitive function across the life course, however, has not yet been evaluated. This Review assesses the evidence for diet supporting cognitive function from childhood into old age.
View Article and Find Full Text PDFIntroduction: Older patients have a higher risk for complications after rectal cancer surgery. Although screening for geriatric impairments may improve risk prediction in this group, it has not been studied previously.
Methods: We retrospectively investigated patients ≥70 years with elective surgery for non-metastatic rectal cancer between 2014 and 2018 in nine Dutch hospitals.