The Burden of Respiratory Syncytial Virus (RSV) in Germany: A Comprehensive Data Analysis Suggests Underdetection of Hospitalisations and Deaths in Adults 60 Years and Older.

Introduction: In Germany, the estimation of the disease burden of respiratory syncytial virus (RSV) in older adults is limited. This makes it challenging for public health decision-makers to develop evidence-based recommendations for newly available vaccines against RSV for individuals aged 60 years and older (60+). This study investigates publicly available data sources in Germany to address the current gaps in evidence regarding the burden of RSV.

On Inactivation of the Coronavirus Main Protease.

A deeper understanding of the inactive conformations of the coronavirus main protease (MPro) could inform the design of allosteric drugs. Based on extensive molecular dynamics simulations, we built a Markov State Model to investigate structural changes that can inactivate the SARS-CoV-2 MPro. In a subset of structures, one subunit of the homodimer assumes an inactive conformation that resembles an inactive crystal structure.

The cost of primary care consultations associated with long COVID in non-hospitalised adults: a retrospective cohort study using UK primary care data.

Background: The economic impact of managing long COVID in primary care is unknown. We estimated the costs of primary care consultations associated with long COVID and explored the relationship between risk factors and costs.

Methods: Data were obtained on non-hospitalised adults from the Clinical Practice Research Datalink Aurum primary care database.

Validation of new ICD-10-based patient safety indicators for identification of in-hospital complications in surgical patients: a study of diagnostic accuracy.

Objective: Administrative data systems are used to identify hospital-based patient safety events; few studies evaluate their accuracy. We assessed the accuracy of a new set of patient safety indicators (PSIs; designed to identify in hospital complications).

Study Design: Prospectively defined analysis of registry data (1 April 2010-29 February 2016) in a Canadian hospital network.

Noise Exposure and Background Noise Tolerance in Listeners With Normal Audiograms.

Purpose Tolerance for background noise when listening to speech has been found to vary greatly between individuals, despite clinically similar audiograms. Recent work suggests that listeners at risk for noise-induced hearing loss (NIHL) self-report greater annoyance of background sounds compared with listeners at lower risk for NIHL. To date, the relationship between noise exposure levels and background noise tolerance has not been studied using objective noise exposure level measurements and quantitative (i.