Optogenetic Control of B. subtilis Gene Expression Using the CcaSR System.

Optogenetics enables precise control of gene expression in a variety of organisms. We recently developed the first system for optogenetic control of transcription in Bacillus subtilis. This system is based on CcaSR, a light-responsive two-component regulatory system originally derived from Synechocystis PCC 6803.

Prototype of a New Head Grabber for Robotic Strawberry Harvesting with a Vision System.

This paper presents the design of a strawberry fruit head gripper unit, together with the concept of a control system for the operation of its mechanisms and vision system. The developed design consists of three specialised mechanisms: positioning, grasping, and cutting off of the fruit. A Finite Element Method (FEM) model was developed for the described design.

Plasma Biomarkers of Traumatic Brain Injury in Adolescents With Sport-Related Concussion.

Importance: Blood-based biomarkers may clarify underlying neuropathology and potentially assist in clinical management of adolescents with sport-related concussion (SRC).

Objective: To investigate the association between SRC and plasma biomarkers in adolescents.

Design, Setting, And Participants: Prospective cohort study in Canadian sport and clinic settings (Surveillance in High Schools and Community Sport to Reduce Concussions and Their Consequences study; September 2019 to November 2022).

Corrigendum to "Decoding phenotypic screening: A comparative analysis of image representations" [Computat Struct Biotechnol J 23 (2024) 1181-1188].

[This corrects the article DOI: 10.1016/j.csbj.

Recruitment of FBXO22 for targeted degradation of NSD2.

Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to target proteins for proteasomal degradation. Here we describe a TPD strategy involving the recruitment of FBXO22 to induce degradation of the histone methyltransferase and oncogene NSD2. UNC8732 facilitates FBXO22-mediated degradation of NSD2 in acute lymphoblastic leukemia cells harboring the NSD2 gain-of-function mutation p.