Publications by authors named "J M Stolz"
Objectives: The present study aimed to compare the tumor growth delay between conventional radiotherapy (CRT) and the spatially fractionated modalities of microbeam radiation therapy (MRT) and minibeam radiation therapy (MBRT). In addition, we also determined the influence of beam width and the peak-to-valley dose ratio (PVDR) on tumor regrowth.
Methods: A549, a human non-small-cell lung cancer cell line, was implanted subcutaneously into the hind leg of female CD1 mice.
Article Synopsis
- Proton Minibeam Radiation Therapy has been promising in enhancing treatment efficacy compared to traditional radiation, but more research into its biological mechanisms is needed.
- A mechanical collimation setup was developed to produce 250µm minibeams with a 1000µm spacing, with optimization using Monte Carlo simulations conducted at various proton therapy sites.
- Results showed a peak-to-valley dose ratio (PVDR) of 10 in Dresden and 14 in Seattle, with some discrepancies between dosimetry methods that can be addressed with correction factors.
Post-traumatic Parkinsonism (PTP) is a complex neurological disorder that is often associated with the occurrence of a traumatic brain injury (TBI). PTP can occur either in the acute or chronic phase of TBI. There is still uncertainty about the mechanisms provoking PTP, which can be the result of the acute blast itself or secondary neurodegenerative process occurring months to years post the acute trauma.
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- Ancestral differences in genomic variation influence gene expression, with most studies focusing on European samples or adjusting for ancestry, rather than specifically examining it.
- This study explored how genetic ancestry impacts gene expression and DNA methylation in brain tissue from admixed Black American individuals, revealing ancestry-related genes primarily involved in immune response and vascular tissue rather than neurons.
- The identified ancestry-associated differentially expressed genes (DEGs) contribute to heritability for various conditions like ischemic stroke, Parkinson's, and Alzheimer's, highlighting significant differences in gene expression based on genetic ancestry and its implications for brain-related illnesses.
Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features, including differential symptomatology, drug responsiveness, and male incidence rate. Prior large-scale transcriptome analyses for sex differences in schizophrenia have focused on the prefrontal cortex. Analyzing BrainSeq Consortium data (caudate nucleus: n = 399, dorsolateral prefrontal cortex: n = 377, and hippocampus: n = 394), we identified 831 unique genes that exhibit sex differences across brain regions, enriched for immune-related pathways.
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