Publications by authors named "J M Sasikumar"
Article Synopsis
- * Phytomedicine, which includes natural compounds like phenolic acids and flavonoids, shows promise as an alternative treatment due to its antifungal properties and other therapeutic effects against Malassezia.
- * Despite its potential, challenges such as lack of standardization, variable effectiveness, and insufficient clinical evidence need to be addressed to effectively integrate phytomedicine into mainstream healthcare for treating Malassezia-related issues.
Malassezia is a lipophilic commensal yeast that resides mainly on the mammalian skin and is also found to associate with the internal organs. Dysbiosis of Malassezia is related to several diseases and often escapes detection as it is difficult to culture and maintain. Malassezia cell wall differs from other budding yeasts like S.
View Article and Find Full Text PDFMCM10 plays a vital role in genome duplication and is crucial for DNA replication initiation, elongation, and termination. It coordinates several proteins to assemble at the fork, form a functional replisome, trigger origin unwinding, and stabilize the replication bubble. MCM10 overexpression is associated with increased aggressiveness in breast, cervical, and several other cancers.
View Article and Find Full Text PDFArticle Synopsis
- The human mycobiome, particularly the fungal community, plays a significant role in health and disease, with recent studies suggesting a link between fungal organisms and neurological disorders.
- The presence of Malassezia, a fungus usually associated with skin and gut issues, has been discovered in the brain and is being investigated for its potential connection to diseases like Alzheimer's and Parkinson's.
- The research highlights how Malassezia might affect the brain through various mechanisms, such as crossing the blood-brain barrier and inducing inflammation, encouraging future collaboration among scientists to explore the gut-brain axis and its implications for human health.
Evidence of fungal coexistence in humans points towards fungal adaptation to the host environment, like the skin. The human commensal Malassezia has evolved, especially residing in sebum-rich areas of the mammalian body where it can get the necessary nutrition for its survival. This fungus is primarily responsible for skin diseases like Pityriasis versicolor (PV), characterized by hypo or hyperpigmented skin discoloration and erythematous macules.
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