Publications by authors named "J M Salas Peregrin"
Fibroblast growth factor (FGF) signaling elicits multiple downstream pathways, most notably the Ras/MAPK cascade facilitated by the adaptor protein Grb2. However, the mechanism by which Grb2 is recruited to the FGF signaling complex remains unresolved. Here we showed that genetic ablation of FGF signaling prevented lens induction by disrupting transcriptional regulation and actin cytoskeletal arrangements, which could be reproduced by deleting the juxtamembrane region of the FGF receptor and rescued by Kras activation.
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- Schlemm's canal (SC) plays a crucial role in regulating intraocular pressure, but its detailed biology is not fully understood, leading researchers to conduct extensive RNA sequencing on significant numbers of Schlemm's canal endothelial cells (SECs).
- The study identified three distinct molecular classes of SECs, differentiating between the inner and outer walls, and discovered variations in the inner wall cells that suggest their functions may be influenced by their local environment.
- Findings highlight the importance of cell junctions in fluid permeability and reveal interactions between SECs and adjacent trabecular meshwork cells, laying a new molecular groundwork for understanding glaucomatous processes and potential treatments.
Background: We would like to present an unusual case of simultaneous stenosis of renal graft artery and vein diagnosed four months after transplantation. both treated by stent placement. Our aim is to point at the fact that renal graft venous stenosis is very rarely reported in the literature and - as it is not easy to diagnose by routine US - it could be overlooked.
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- Schlemm's canal (SC) plays a crucial role in regulating intraocular pressure, but its properties and functions need further investigation, particularly the different types of endothelial cells (SECs) in its inner and outer walls.
- The study utilized bulk RNA sequencing and single-cell RNA sequencing on SECs to identify molecular characteristics, confirming a lymphatic phenotype predominate in SC and highlighting the importance of cell junctions in fluid permeability.
- The research identifies three distinct classes of SECs, reveals their interactions with trabecular meshwork cells, and lays a molecular groundwork for understanding and treating conditions like glaucoma.
In albinism, aberrations in the ipsi-/contralateral retinal ganglion cell (RGC) ratio compromise the functional integrity of the binocular circuit. Here, we focus on the mouse ciliary margin zone (CMZ), a neurogenic niche at the embryonic peripheral retina, to investigate developmental processes regulating RGC neurogenesis and identity acquisition. We found that the mouse ventral CMZ generates predominantly ipsilaterally projecting RGCs, but this output is altered in the albino visual system because of CyclinD2 downregulation and disturbed timing of the cell cycle.
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