N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands.

A series of meta-substituted acetophenone derivatives, encompassing N-(alkyloxycarbonyl)thiophene sulfonamide fragments have been synthesized. Several selective AT2 receptor ligands were identified, among those a tert-butylimidazole derivative (20) with a K of 9.3 nM, that demonstrates a high stability in human liver microsomes (t = 62 min) and in human hepatocytes (t = 194 min).

Thoracic outlet syndrome: the Suburban Hospital experience.

Thoracic outlet syndrome (TOS) embodies a constellation of symptoms arising from compression of the nerves, arteries, and veins at the base of the neck. Symptoms may vary in distribution and intensity, depending on which of the three structures in the neurovascular bundle are involved. The majority of patients benefit from nonsurgical management; however, when surgery is indicated, transaxillary first rib resection has a high degree of acceptance from patients and surgeons.

Inflammatory abdominal aortic aneurysm masquerading as occlusion of the inferior vena cava.

Inflammatory aneurysms are an uncommon disorder that represent between 5% and 10% of abdominal aortic aneurysms. Their presentation is often variable and may include pain and obstruction of adjacent anatomic structures. This report describes a 68-year-old man who sought treatment after insidious onset of progressive bilateral lower extremity edema over a 6-month period.