Proteomic Analysis of Urinary Extracellular Vesicles from Patients with ADTKD-HNF1β identifies roles for Cilia-related Proteins and Serpins.

Autosomal dominant tubulointerstitial kidney disease-subtype hepatocyte nuclear factor 1β (ADTKD-HNF1β) is caused by pathogenic variants in or deletions of the gene encoding transcription factor HNF1β. Patients with the same mutation have variable renal and extrarenal phenotypes, including renal cysts, diabetes, and electrolyte disturbances. The aim of this exploratory study was to provide insight whether pathophysiological effects in the kidney of ADTKD-HNF1β patients are visible by analysing their urinary extracellular vesicle (uEV) proteome.

A distal convoluted tubule-specific isoform of murine SLC41A3 extrudes magnesium.

Background: The distal convoluted tubule (DCT) plays an indispensable role in magnesium (Mg) reabsorption in the kidney. Yet, the extrusion mechanism of Mg has not been identified. The solute carrier 41A3 (SLC41A3) has been suggested to be involved in Mg extrusion, but this has never been conclusively demonstrated.

Evaluation of complications and biochemical recurrence rates after (super) extended lymph node dissection during radical prostatectomy.

Objective: To evaluate the effectiveness of extended (e-PLND) and super-extended pelvic lymph node dissection (se-PLND) during robot-assisted radical prostatectomy (RARP) by examining lymph node (LN) yield, complications, LN metastasis, and biochemical recurrence (BCR) incidence.

Methods: Between January 2016 and January 2020, 354 consecutive patients with > 5% risk of lymph node involvement (LNI), as predicted by the Memorial Sloan Kettering Cancer Center nomogram, underwent RARP with (s)e-PLND at a high-volume center. The e-PLND involved removing fibrofatty lymphatic tissue around the obturator fossa, internal iliac region, and external iliac vessels.

variants cause cardiac dysfunction in a zebrafish model.

The Ras-related GTP-binding protein D () gene plays a crucial role in cellular processes. Recently, variants found in patients have been implicated in a novel disorder with kidney tubulopathy and dilated cardiomyopathy. Currently, the consequences of variants at the organismal level are unknown.