The marine and estuarine bony fishes (Teleostei) of the Golfão Maranhense on the eastern Amazon coast, northern Brazil.

The Golfão Maranhense is an extensive estuarine complex that provides nursery grounds and other habitats for several fish species, as well as a wealth of resources for the coastal and estuarine artisanal fisheries of the Maranhão state, in northern Brazil. The present study provides a comprehensive inventory of marine and estuarine teleost fishes of the Golfão Maranhense based on field samplings, analyses of voucher specimens from local collections and literature data. This inventory presents a total of 163 species of teleosts belonging to 107 genera, 57 families and 27 orders.

Interleukin 24 Promotes Mitochondrial Dysfunction, Glucose Regulation, and Apoptosis by Inactivating Glycogen Synthase Kinase 3 Beta in Human Prostate Cancer Cells.

Interleukin 24 (IL-24) is a tumor-suppressing protein currently in clinical trials. We previously demonstrated that IL-24 leads to apoptosis in cancer cells through protein kinase A (PKA) activation in human breast cancer cells. To better understand the mechanism by which IL-24 induces apoptosis, we analyzed the role of glycogen synthase kinase-3 beta (GSK3β), a highly conserved serine/threonine kinase in cancer cells and a downstream target of PKA.

Lamin B loss in nuclear blebs is rupture dependent while increased DNA damage is rupture independent.

The nucleus houses genetic information and functions separate from the rest of the cell. Loss of nuclear shape results in nuclear ruptures. Nuclear blebs are deformations identified by decreased DNA density, while lamin B levels vary drastically.

Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb.

Focal cortical dysplasia (FCD) is a malformation of cortical development characterized by a heterogeneous group of lesions with high epileptogenic activity. Somatic mutations in the mTOR pathway are the primary cause of cortical malformations (MCDs). Activation of the WNT pathway inhibits GSK3, which is a key inhibitor of mTOR; consequently, WNT activation is associated with increased activation of the mTOR pathway.

Immunoprotection Provided by Salivary and Intestinal Protein-Based Antigens Against the Ixodid Tick .

is among the most dangerous ticks in South America, as it is the species most associated with humans and is the main vector of . In the face of the problems related to tick control based on chemical acaricides, vaccines emerge as a promising method. In previous works, three salivary recombinant proteins (rAs8.