Publications by authors named "J M Rower"
Pediatric asthma exacerbations represent a significant cause of emergency department use and hospitalizations. Despite available treatment options, many children's exacerbations are refractory to standard therapies and require adjunct treatments. The Intravenous Magnesium: Prompt use for Asthma in Children Treated in the Emergency Department study investigated the pharmacology of intravenous magnesium sulfate (IVMg) in treating pediatric asthma exacerbations.
View Article and Find Full Text PDFBackground: Azithromycin and methylprednisolone are two medications that are commonly used in patients who require ECMO support. Unfortunately, ECMO support can decrease drug concentrations through adsorption to circuit components. Such interactions have not been well described for either azithromycin or methylprednisolone.
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- This study focuses on developing a pharmacokinetic model for the drug anakinra in critically ill children undergoing extracorporeal life support (ECLS), which includes continuous renal replacement therapy (CRRT) and ECMO.
- The model was initially created for healthy individuals and then adapted to account for the physiological changes and drug clearance activities related to ECLS in pediatric patients.
- Results indicated that the model accurately predicted anakinra plasma concentrations in adolescents receiving ECLS, suggesting that the dosing recommendations could help improve pharmacotherapy in critically ill children.
Article Synopsis
- The study investigates the combination of clobazam and sodium valproate with additional drugs (stiripentol, cannabidiol, lorcaserin, or fenfluramine) to improve seizure control in a mouse model of Dravet syndrome (DS).
- Researchers assessed the efficacy of these drug combinations against seizures triggered by hyperthermia and measured drug concentrations in the plasma and brain tissues using advanced analytical techniques.
- Results showed that higher doses of stiripentol or cannabidiol combined with clobazam and sodium valproate significantly reduced seizures, suggesting that polypharmacy could effectively improve treatment strategies for Dravet syndrome.
Genetic variation among inhaled corticosteroid (ICS)-metabolizing enzymes may affect asthma control, but evidence is limited. This study tested the hypothesis that single-nucleotide polymorphisms (SNPs) in Cytochrome P450 3A5 (CYP3A5) would affect asthma outcomes. Patients aged 2-18 years with persistent asthma were recruited to use the electronic AsthmaTracker (e-AT), a self-monitoring tool that records weekly asthma control, medication use, and asthma outcomes.
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