Publications by authors named "J M Rollinger"
Background: Dry eye disease (DED) is caused by inflammation on the ocular surface and insufficient quality or production of the tear film. Due to various harmful environmental conditions, a gradual increase of DED cases has been reported.
Hypothesis/purpose: This study aims for a comprehensive in vitro pharmacological and phytochemical profiling of two different Buddleja officinalis Maxim.
Biochemometrics has emerged as promising strategy for the targeted identification of bioactive constituents from natural sources. It is based on the correlation of bioactivity data with chemical data to reveal constituents contributing to activity. Providing complementary data and structural information, MS- and NMR-based biochemometric approaches have both been separately applied in the past.
View Article and Find Full Text PDFArticle Synopsis
- Alternaria mycotoxins can significantly impact food safety and public health, showing various negative effects, but detailed information on their immune system and estrogenic effects is limited.
- The study focused on identifying which specific mycotoxins from Alternaria alternata, grown on rice, contribute to immunosuppressive and antiestrogenic effects using advanced fractionation and analysis methods.
- Results indicated that while certain mycotoxins (ATX-I and ALTP) suppress immune responses and estrogen activity, others like AOH and TeA had minimal or no effect, highlighting the need for further research on their health risks and mechanisms.
Mulberry Diels-Alder-type adducts (MDAAs), isolated from root bark, exhibit dual activity against viral and bacterial pathogens but show sobering efficacy following oral administration. Inhalation administration may overcome issues with oral bioavailability and improve efficacy for the treatment of respiratory infections. To assess the suitability of MDAAs for inhalation administration, physicochemical (e.
View Article and Find Full Text PDFThe average age of the population is increasing worldwide, which has a profound impact on our society. This leads to an increasing demand for medicines and requires the development of new strategies to promote health during the additional years. In the search for resources and therapeutics for improved health during an extended life span, attention has to be paid to environmental exposure and ecosystem burdens that inevitably emerge with the extended consumption of medicines and drug development, even in the preclinical stage.
View Article and Find Full Text PDF