Publications by authors named "J M Rodriguez-Robledo"
Article Synopsis
- - Hypothyroidism causes changes in heart electrical activity that can lead to dangerous heart rhythms (arrhythmias), particularly influenced by high levels of thyrotropin (TSH), which is linked to worse health outcomes.
- - Researchers created two rat models to study the effects of low and high TSH levels on the heart, using methods like electrocardiograms and measuring ionic currents in heart cells.
- - While both hypothyroidism models showed increased calcium currents, only the primary hypothyroidism model (high TSH) had notable heart rhythm issues; TSH treatment also altered heart cell activity and decreased important potassium currents in myocytes.
Aims: The fast transient outward current, I(to,fast) , is the most extensively studied cardiac K(+) current in diabetic animals. Two hypotheses have been proposed to explain how type-1 diabetes reduces this current in cardiac muscle. The first one is a deficiency in channel expression due to a defect in the trophic effect of insulin.
View Article and Find Full Text PDF