Publications by authors named "J M Rodriguez-Martinez"
Article Synopsis
- This study focuses on creating a biocompatible, acellular graft from human pericardium for tissue engineering by using a decellularization process to mimic the natural extracellular matrix.
- The decellularization was achieved through enzymatic and hypertonic methods, with histological analyses confirming the absence of cells while maintaining ECM structural integrity.
- The results showed that the acellular graft retained key biomolecules and mechanical properties, indicating its potential for various clinical applications.
Article Synopsis
- The work focuses on constructing a stable two-dimensional system using known 2D arsenic and phosphorus compounds with various structural symmetries, specifically hexagonal and orthorhombic.
- Phonon spectra calculations confirmed that all modeled structures exhibit dynamical stability, while cohesive energies and elastic constants ensured their thermodynamic and mechanical stabilities.
- Additionally, first-principles studies were conducted to assess the electronic and optical properties, revealing potential applications for the 2D As-P systems due to their favorable characteristics.
Scientists have established a connection between environmental exposure to toxins like β--methylamino-l-alanine (BMAA) and a heightened risk of neurodegenerative disorders. BMAA is a byproduct from certain strains of cyanobacteria that are present in ecosystems worldwide and is renowned for its bioaccumulation and biomagnification in seafood. The sensitivity, selectivity, and reproducibility of the current analytical techniques are insufficient to support efforts regarding food safety and environment monitoring adequately.
View Article and Find Full Text PDFIn recent years, new evidence has shown that the SOS response plays an important role in the response to antimicrobials, with involvement in the generation of clinical resistance. Here we evaluate the impact of heterogeneous expression of the SOS response in clinical isolates of Escherichia coli on response to the fluoroquinolone, ciprofloxacin. In silico analysis of whole genome sequencing data showed remarkable sequence conservation of the SOS response regulators, RecA and LexA.
View Article and Find Full Text PDFIntroduction/objective: Suppression of the SOS response in combination with drugs damaging DNA has been proposed as a potential target to tackle antimicrobial resistance. The SOS response is the pathway used to repair bacterial DNA damage induced by antimicrobials such as quinolones. The extent of -regulated protein expression and other associated systems under pressure of agents that damage bacterial DNA in clinical isolates remains unclear.
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