Publications by authors named "J M Riordan"
The Rac1 P29S hotspot mutation in cutaneous melanoma is associated with resistance to MAPK pathway inhibitors (MAPKi) and worse clinical outcomes. Moreover, activation of Rac1 guanine exchange factors (GEFs) also promotes MAPKi-resistance, particularly in undifferentiated melanoma cells. Here we delineate mechanisms of Rac1-driven MAPKi-resistance and identify strategies to inhibit the growth of this class of cutaneous melanomas.
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- Delirium is a common complication for older adults after hip fracture surgery, with a study analyzing patient data from 2015-2020 revealing inconsistent links between the type of anaesthesia used and the occurrence of delirium.
- Among the 35,252 patients studied, those who received general anaesthesia (40.6%) showed higher rates of delirium compared to those who received spinal or regional anaesthesia (35.7%).
- Adjustments for known confounders indicated a weak association between general anaesthesia and delirium, but an analysis addressing unmeasured factors found no significant causal link, suggesting more research is needed in this area.
Purpose: Patients with cancer face complex challenges that often lead them to seek care in emergency departments (EDs) for acute symptoms and complications. While previous studies have examined preventable ED visits by patients with cancer, less attention has focused on frequent ED use in this population. This study aimed to explore the temporal visit patterns of frequent ED users with cancer.
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- Raynaud's phenomenon causes reduced blood flow in fingers and skin due to cold or stress, classified into primary and secondary forms, with the latter linked to various health issues.
- A clinical case of a 51-year-old male highlights the need for thorough evaluations to rule out serious conditions, showing the complexity of diagnosing Raynaud's.
- Management includes lifestyle changes and medications like calcium channel blockers, with advanced therapies available for severe cases, emphasizing the importance of personalized treatment for better outcomes.
Anthocyanin-rich edible berries protect against diet-induced obesity in animal models. Prevention is mediated through the bidirectional relationship with the fecal microbiome, and gut-derived phenolic metabolite absorption increases with physical activity, which may influence bioactivity. The objective of this study was to test elderberry juice powder on the development of diet-induced obesity and its influence on the fecal microbiome alone or in combination with physical activity.
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