Publications by authors named "J M Rien Nijman"
In this study we replicated a typical high-quality post-consumer polypropylene (PP) recycling process to investigate its losses and emissions and study potential improvements. To our knowledge this is the first time that quantitative measurements on all process steps have been performed instead of an accumulated yield and emissions in water. In the process an overall PP yield of 85 wt% based on pure PP input is achieved.
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- The CRUCIAL trial is studying the impact of allopurinol on brain injury in newborns with critical congenital heart disease (CCHD) undergoing heart surgery.
- The aim is to understand how the drug is metabolized (pharmacokinetics) during different surgical phases and to see if current dosing achieves effective drug levels.
- Results showed a complex drug absorption model with a 100% target attainment for allopurinol levels immediately after birth, but varying success rates during the surgical process, indicating adjustments may be needed in administration timing or dosage.
Background: The treatment of preterm and low birth weight (LBW) neonates born with congenital heart disease (CHD) requiring early cardiac intervention remains challenging. We aimed to analyze morbidity and mortality in this combined high-risk patient group.
Methods: A retrospective cohort study was conducted of preterm [<37 weeks gestational age (GA)] and/or LBW neonates (<2,500 g) born with a diagnosis of CHD, which requires invasive cardiac intervention (surgery or catheter) within their first year of life.
Objective: To examine the relationship between perioperative brain injury and neurodevelopment during early childhood in patients with severe congenital heart disease (CHD).
Study Design: One hundred and seventy children with CHD and born at term who required cardiopulmonary bypass surgery in the first 6 weeks after birth were recruited from 3 European centers and underwent preoperative and postoperative brain MRIs. Uniform description of imaging findings was performed and an overall brain injury score was created, based on the sum of the worst preoperative or postoperative brain injury subscores.