A pragmatic approach to selecting a grading system for clinical practice recommendations in palliative care.

Background: The limited palliative care evidence base is poorly amenable to existing grading schemes utilized in guidelines. Many recommendations are based on expert consensus or clinical practice standards, which are often considered 'low-quality' evidence. Reinforcing provider hesitancy in translating recommendations to practice has implications for patient care.

Methadone for Pain Management in Chemotherapy-Induced Peripheral Neuropathy: A Retrospective Review.

Chemotherapy-Induced Peripheral Neuropathy (CIPN) refers to damage of peripheral nerve fibers due to the use of neurotoxic chemotherapy to treat various cancers. It occurs in more than 30% of patients and only duloxetine has currently been identified to show limited efficacy in symptomatic treatment of CIPN. Opioids have traditionally been used to treat cancer pain, and there is evidence for their use in treatment of peripheral neuropathic pain from other causes.

Modelling environmental life cycle performance of alternative marine power configurations with an integrated experimental assessment approach: A case study of an inland passenger barge.

There is pressure on the global shipping industry to move towards greener propulsion and fuel technologies to reduce greenhouse gas emissions. Hydrogen and electricity are both recognised as pathways to achieve a net-zero. However, in the evaluation of the environmental performance of these alternative marine power configurations, conventional life cycle assessment (LCA) methods have limitations reflecting the varied nature of ship design and operational modes.

Developing rights-based standards for children having tests, treatments, examinations and interventions: using a collaborative, multi-phased, multi-method and multi-stakeholder approach to build consensus.

Children continue to experience harm when undergoing clinical procedures despite increased evidence of the need to improve the provision of child-centred care. The international ISupport collaboration aimed to develop standards to outline and explain good procedural practice and the rights of children within the context of a clinical procedure. The rights-based standards for children undergoing tests, treatments, investigations, examinations and interventions were developed using an iterative, multi-phased, multi-method and multi-stakeholder consensus building approach.