Publications by authors named "J M Rakic"
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder affecting women's reproductive health, often leading to infertility and metabolic issues.
- Research has highlighted the role of metformin in managing PCOS, but new treatments like SGLT2 inhibitors (SGLT2is) are emerging as promising options for improving metabolic health in these patients.
- A study using the drug empagliflozin (EMPA) in a PCOS rat model showed positive effects on metabolism, hormone levels, and ovarian function, suggesting its potential as an effective alternative to metformin for managing PCOS.
Due to an increase in the worldwide prevalence of obesity and the efficiency of bariatric surgery, this procedure is more often performed. Besides its benefits, it has also disadvantages and may be the cause of nutritional deficiencies. Thiamin deficiency is particularly important to diagnose and to treat early as it can lead to major sequelae and even to death.
View Article and Find Full Text PDFThe management of optic neuropathy is fundamental to neuro-ophthalmic practice. Following the invention of the ophthalmoscope, clinicians, for a century or more, relied upon fundus examination in the evaluation of optic neuropathy. However, the advent of optical coherence tomography, based on the principle of backscattering of light and interferometry, has revolutionized the analysis of optic nerve and retinal disorders.
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- African American smokers have a 2.5 times higher risk for stroke compared to nonsmokers, influenced by genetic variants (G1 and G2) of the apolipoprotein L1 gene that are more common in this population.
- A study involving 513 African American adults found that carriers of these genetic variants showed a significantly higher association between smoking and stroke prevalence, indicating that these genetic factors may increase stroke risk for current and former smokers.
- The findings suggest that African American smokers with these genetic risk variants are more vulnerable to stroke, whereas noncarriers did not show a similar correlation between smoking and stroke risk.