Publications by authors named "J M R Gerris"
Research Question: Ovarian stimulation during IVF cycles involves close monitoring of oestradiol, progesterone and ultrasound measurements of follicle growth. In contrast to blood draws, sampling saliva is less invasive. Here, a blind validation is presented of a novel saliva-based oestradiol and progesterone assay carried out in samples collected in independent IVF clinics.
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- CEP78 gene variants are linked to a specific condition called cone-rod dystrophy with hearing loss (CRDHL), which differs from Usher syndrome.
- Researchers identified a new missense variant, c.449T>C, p.(Leu150Ser), in multiple families, indicating a potential founder effect.
- The variant affects protein stability and is associated with elongated primary cilia, sperm abnormalities, and even male infertility, suggesting that CEP78's role in related conditions may be broader than previously thought.
Aim Of The Study: Investigation of the correlation between serum estradiol (E2), salivary E2 and sonographic measurements of follicles in women undergoing controlled ovarian stimulation (COS) for IVF/ICSI.
Methods: This is a prospective study performed at the Department of Reproductive Medicine of Ghent University Hospital (Belgium) between November 2016 and January 2017 over a total of 40 patients. During routine COS, two-dimensional measurements of the follicles were performed using transvaginal ultrasound (TVUS) and E2 was measured in saliva and serum.
Background: Freezing all embryos generated during an IVF/ICSI attempt is used increasingly as a strategy to optimize results. We investigated whether we could find differences in outcome between subpopulations of patients undergoing the so-called "freeze all" procedure.
Methods: Non-interventional, observational, retrospective study of 131 freeze-all cycles performed between July 2015 and December 2016 at the University Hospital of Ghent (Belgium).