Publications by authors named "J M Pyman"
Background: In 2007, Australia introduced a national human papillomavirus (HPV) vaccination program. In 2017, the onset of cervical screening changed from 18 to 25 years of age, utilising human papillomavirus (HPV) nucleic acid testing. The objective of the study is to describe the HPV genotypes and HPV16 variants in biopsies from women ≤ 25 years of age with cervical carcinoma (CC) (cases), compared with those aged >25 years (controls), in a pre-vaccination cohort.
View Article and Find Full Text PDFStandard molecular classification of endometrial cancers (EC) is now endorsed by the WHO and identifies p53-abnormal (p53abn) EC as the subgroup with the poorest prognosis and the most likely to benefit from adjuvant chemo(radio)therapy. P53abn EC are POLE wildtype, mismatch repair proficient and show abnormal immunohistochemical (IHC) staining for p53. Correct interpretation of routinely performed p53 IHC has therefore become of paramount importance.
View Article and Find Full Text PDFTo make accurate determinations regarding potential and actual impact of HPV vaccine programs, precise estimates of genotype-specific contributions to disease are required for pre- and post-vaccine populations. Definitive determination of lesion-specific genotypes, particularly where multiple genotypes are detected in a sample, can be technically demanding and resource intensive; therefore, most prevalence studies use mathematical algorithms to adjust for multiple genotype detections. There are currently several algorithms, which can produce genotype estimates within a wide range of variability.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze the presence of HPV types in cervical lesions among young women in Victoria, Australia, as part of ongoing vaccine impact evaluation after catch-up HPV vaccinations were offered.
- Using advanced techniques, researchers compared the HPV types found in biopsies from vaccinated women to pre-vaccination data, showing a decrease in the prevalence of HPV16/18 in younger women over time.
- Results indicated that post-vaccine, HPV16/18 accounted for about 47% of CIN3/AIS in 18-25 year-olds by 2013-2014, while nonavalent vaccine types were found in 80-90% of cases, highlighting the vaccine's effectiveness.
Background: This long-term consecutive, retrospective single-center cohort study evaluates long-term outcomes of single-event multilevel surgery in diplegic cerebral palsy with respect to functional status, gait, and patient satisfaction.
Methods: All patients with diplegic cerebral palsy who underwent single-event multilevel surgery >10 years previously were included. Retrospective gait assessment was performed using the Edinburgh Visual Gait Score (EVGS) and Gillette Functional Assessment Questionnaire Walking Scale (FAQWS) preoperatively and at midterm postoperative follow-up (median 2.