Publications by authors named "J M Portos"
Objective: This retrospective single center study aims to describe changes in the severity and organ-specific distribution of GvHD, by comparing the outcomes of 3 distinct GvHD prophylaxis approaches.
Methods: Between January 2012 and June 2022, 226 patients underwent allogeneic hematopoietic stem cell transplantation from HLA-matched or 1-allele mismatched related or unrelated donors. Fifty-eight (26%) received prophylaxis with calcineurin inhibitor in combination with mycophenolate mofetil or a short course of methotrexate (Cohort-1), 87 (38%) tacrolimus plus sirolimus (Cohort-2), and 81 (36%) post-transplant cyclophosphamide (PTCy) plus tacrolimus (Cohort-3).
Home hospitalization represents an alternative to traditional hospitalization, providing comparable clinical safety for hematological patients. At-home therapies can range from the delivery of intravenous antibiotics to more complex scenarios, such as the care during the early period after hematopoietic stem cell transplantation and chimeric antigen receptor T-cell therapy. Early discharge from conventional hospitalization is feasible and helps reduce hospital resources and waiting lists.
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- Bone marrow harvesting is crucial for stem cell transplantation, and due to the unavailability of commercial kits in Europe since 2019, researchers developed an in-house alternative.
- A study was conducted comparing the in-house kit with a commercial kit, assessing various quality metrics and noting any complications during the collection process across 23 donors for each type.
- Results showed no significant differences in harvest quality or engraftment times, but the in-house kit had a higher incidence of filter clogging, indicating a possible limitation.
Article Synopsis
- Scientists did a study on 14 patients with a serious condition called myelofibrosis who got a special type of treatment called allo-HCT.
- They used lower doses of medicine to help prevent complications, and most patients showed good recovery without any graft failures.
- After following the patients for a while, they found that many were still alive and healthy, with low chances of serious problems from the treatment.
Objectives: High-dose total body irradiation (TBI) is considered a cornerstone of myeloablative conditioning for allogeneic stem cell transplantation (allo-SCT). We retrospectively compared the main outcomes of an HLA matched or 1-allele mismatched related or unrelated allo-SCT in adult patients affected by acute leukemia (AL) or myelodysplastic syndromes (MDS).
Methods: Fifty-nine patients received cyclophosphamide (Cy)-TBI (13.