Publications by authors named "J M Portoles"

Article Synopsis
  • Gut dysbiosis in chronic kidney disease (CKD) has been linked to anemia due to factors like increased uremic toxins, inflammation from gut barrier issues, and reduced production of beneficial short-chain fatty acids (SCFAs).
  • Addressing gut dysbiosis can help manage anemia in CKD patients by reducing harmful medications, incorporating dietary changes, and using prebiotics or probiotics to enhance beneficial gut bacteria.
  • Improving gut health in CKD not only alleviates anemia symptoms but can also boost the effectiveness of treatments like erythropoiesis-stimulating agents (ESAs) in patients unresponsive to standard therapies.
View Article and Find Full Text PDF

Background: Post-transplant anemia is a prevalent yet often overlooked condition that poses significant risks. Current guidelines consider the same treatment recommendations and goals for these patients as for chronic kidney disease patients not on dialysis. Previous reports demonstrated a lack of awareness and suboptimal management, indicating a pressing need for improvement.

View Article and Find Full Text PDF

GLP-1 receptor agonists (GLP-1RAs) have emerged as fundamental components in the treatment of type 2 diabetic patients (T2DM) with chronic kidney disease (CKD). The oral formulation represents a novel therapeutic tool but may affect drug efficacy. This study sought to compare the effectiveness of subcutaneous versus oral semaglutide formulations in patients with CKD.

View Article and Find Full Text PDF

: Acute kidney injury (AKI) significantly disrupts vital renal functions and is a common and serious condition in intensive care units (ICUs). AKI leads to extended hospital stays, increases mortality rates, and often necessitates nephrology consultations. Continuous renal replacement therapy (CRRT) plays a central role in managing AKI, requiring a multidisciplinary approach involving nephrologists, intensivists, and anesthesiologists.

View Article and Find Full Text PDF

Anaemia is common in chronic kidney disease (CKD) and has a significant impact on quality of life (QoL), work productivity and outcomes. Current management includes oral or intravenous iron and erythropoiesis-stimulating agents (ESAs), to which hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have been recently added, increasing the available therapeutic options. In randomised controlled trials, only intravenous iron improved cardiovascular outcome, while some ESAs were associated with increased adverse cardiovascular events.

View Article and Find Full Text PDF