Publications by authors named "J M Piccione"
Granulomatous hyperinflammatory state induced by dupilumab treatment for eosinophilic esophagitis.
J Allergy Clin Immunol Glob
November 2024
We present the first case of a dupilumab-induced hyperinflammatory state in the setting of underlying eosinophilic esophagitis characterized by multisystem granulomatous inflammation. Although clinical trial data and subsequent real-world experience support dupilumab as a highly effective therapy for eosinophilic esophagitis, close monitoring for development of adverse symptoms following initiation remains paramount.
View Article and Find Full Text PDFImpact of a tracheal aspirate culture diagnostic test stewardship intervention in a tertiary care PICU.
Infect Control Hosp Epidemiol
September 2024
Article Synopsis
- * The intervention involved creating guidelines to reduce unnecessary cultures, resulting in a decline from 4.3 to 2.3 cultures per 100 ventilator days after implementation, alongside a decrease in antibiotic treatments for infections.
- * Overall, the intervention was deemed safe, showing no negative impact on patient outcomes such as mortality or readmissions while successfully lowering the rates of cultures and antibiotic usage.