Publications by authors named "J M Pfeil"
Retinopathy of prematurity in Germany over 13 years: incidences, treatment preferences and effects of national guideline changes.
Arch Dis Child Fetal Neonatal Ed
December 2024
Objective: Retinopathy of prematurity (ROP) is a leading yet avoidable cause of childhood blindness. Screening for ROP is highly effective in preventing blindness secondary to ROP. We provide epidemiological data on ROP screening and treatment in Germany since 2010 and evaluate the effects of recently adopted as well as potential future screening guideline adaptations.
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- The study addresses the need for predictive biomarkers for the effectiveness of immune checkpoint inhibitors (ICIs) in treating non-small cell lung cancer (NSCLC) using data from two clinical trials.
- A competition, the Anti-PD-1 Response Prediction DREAM Challenge, involved 59 teams submitting 417 predictive models based on various biological variables to forecast patient outcomes with ICIs.
- The results indicate that the best models outperformed existing reference variables like tumor mutational burden (TMB) and PD-L1 expression, potentially paving the way for future research in other cancers with similar approaches.
Purpose: To analyze changes in demographic parameters and retreatment patterns over a 10-year period in a clinical routine setting of infants with retinopathy of prematurity (ROP) requiring treatment documented in the German Retina.net ROP registry.
Design: Multicenter, noninterventional, observational registry study recruiting patients treated for ROP.
Purpose: The German Retina.net ROP registry and its Europe-wide successor, the EU-ROP registry, collect data from patients treated for ROP. This analysis compares input parameters of these two registries to establish a procedure for joint analyses of different registry data using exemplary datasets from the two registries.
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- Vessel-associated retinal diseases, such as age-related macular degeneration (AMD) and diabetic retinopathy (DR), are significant causes of blindness, and identifying biomarkers can help in tracking disease progression and developing targeted treatments.
- This study focuses on the presence of specific microRNAs (miRNAs) in the serum and vitreous of patients with these diseases, using quantitative real-time PCR to compare their levels to control patients.
- Results indicate that certain miRNAs, like miR-29a-3p and miR-192-5p, show increased expression in patients with neovascular AMD and proliferative DR, suggesting these miRNAs could serve as potential biomarkers for these conditions.