Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis.

Obesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how MCJ expression decreases during obesity, as evident in human and mouse adipose tissue samples.

Results of a patient-level pooled analysis of three studies of trastuzumab deruxtecan in HER2-positive breast cancer with active brain metastasis.

Background: Brain metastases (BMs) are common in human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer, increasing morbidity and mortality. Systemic therapy for BMs can be effective, with the triple combination of trastuzumab, capecitabine, and tucatinib being a potential standard. More recently, intracranial activity of antibody-drug conjugates has been reported, but the size of individual studies has been small.

Potential feeding sites for seabirds and marine mammals reveal large overlap with offshore wind energy development worldwide.

Offshore wind energy is experiencing accelerated growth worldwide to support global net zero ambitions. To ensure responsible development and to protect the natural environment, it is essential to understand and mitigate the potential impacts on wildlife, particularly on seabirds and marine mammals. However, fully understanding the effects of offshore wind energy production requires characterising its global geographic occurrence and its potential overlap with marine species.

Patterns of immune evasion in triple-negative breast cancer and new potential therapeutic targets: a review.

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the absence of progesterone and estrogen receptors and low (or absent) HER2 expression. TNBC accounts for 15-20% of all breast cancers. It is associated with younger age, a higher mutational burden, and an increased risk of recurrence and mortality.

Guidelines for species descriptions of free-living aquatic nematodes: characters, measurements and their presentation in taxonomic publications.

Free-living aquatic nematodes are abundant, diverse and of general environmental importance. However, knowledge of species distributions of both marine and freshwater nematodes is sparse. Species distribution data are crucial for evaluating environmental impacts from human activities and to conduct integrated nematode community assessments.