Publications by authors named "J M Osca"
Background: The optimal radiofrequency application (RFa) parameters for safe and durable pulmonary vein isolation (PVI) are debated. High-power short-duration (HPSD) has been used as an alternative to conventional power delivery (CPD).
Objectives: This study sought to compare HPSD 70 W/9-10 s (HPSD-70) with CPD 25-40 W in patients undergoing PVI.
Influence of genetic mutations to atria vulnerability to atrial fibrillation: An in-silico 3D human atria study.
Comput Methods Programs Biomed
September 2024
Article Synopsis
- - The study investigates how specific genetic mutations related to potassium channels affect the susceptibility to atrial fibrillation (AF) using advanced 3D computer models of the atria, highlighting the use of realistic anatomical features.
- - By simulating ectopic foci and evaluating electrical activity, the research found that the KCNE3-V17M mutation significantly shortens action potentials and is highly linked to arrhythmias, whereas KCNH2 mutations also increase vulnerability but to a lesser extent.
- - Results showed that 60% of arrhythmic events occurred in the left atrium, with complex electrical patterns like spiral waves contributing to the development of AF, indicating the importance of genetic factors in understanding arrhythmic risks
Article Synopsis
- Pulsed field ablation (PFA) is a new method for treating atrial fibrillation (AF) that focuses on ablating heart tissue while minimizing harm to nearby structures.
- In the MANIFEST-17K study, data from 106 centers involved 17,642 patients and showed no serious complications like esophageal damage, with only a 1% major complication rate.
- The results suggest that PFA has a strong safety profile and may change how AF is treated, compared to traditional thermal ablation methods.
Background: Lumenless leads (LLLs) are widely used for left bundle branch area pacing (LBBAP). Recently, stylet-driven leads (SDLs) have also been used for LBBAP.
Objective: The purpose of this study was to evaluate the acute performance of SDLs during LBBAP in comparison with LLLs.
Cardiac resynchronization therapy (CRT) via biventricular pacing (BiVP-CRT) is considered a mainstay treatment for symptomatic heart failure patients with reduced ejection fraction and wide QRS. However, up to one-third of patients receiving BiVP-CRT are considered non-responders to the therapy. Multiple strategies have been proposed to maximize the percentage of CRT responders including two new physiological pacing modalities that have emerged in recent years: His bundle pacing (HBP) and left bundle branch area pacing (LBBAP).
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