Publications by authors named "J M Oors"
Objectives: It is thought that esophageal hypersensitivity in combination with an impaired mucosal barrier function contributes to PPI-resistant reflux symptoms. Ziverel, a bioadhesive agent that coats the esophageal wall, was shown to have a positive effect on reflux symptoms. However, the mechanisms of action are unclear.
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- A study was conducted to explore how STW5 (Iberogast) might alleviate heartburn in patients with functional dyspepsia and reflux symptoms, focusing on its effect on esophageal sensitivity and motility.
- In a double-blind, placebo-controlled trial with 18 patients, STW5 showed no significant difference overall in reflux symptom scores compared to placebo, but it did reduce certain specific scores related to gastroesophageal reflux disease.
- The treatment also demonstrated a reduction in acidic reflux events in patients with gastroesophageal reflux disease and increased time before acid perception in those with reflux esophagitis, suggesting STW5 may help reduce esophageal hypersensitivity.
Objectives: Our objective was to investigate if there is a difference in the detection of the rectoanal inhibitory reflex (RAIR) when an anorectal manometry (ARM) is performed awake or under general anesthesia.
Methods: A retrospective review of ARM studies was performed to identify children who had undergone ARMs both while awake and under general anesthesia. We compared ARM outcomes including the detection of the RAIR and anal canal resting pressure.
Introduction: Although inability to belch has previously been linked to dysfunction of the upper esophageal sphincter (UES), its underlying pathogenesis remains unclear. Our aim was to study mechanisms underlying inability to belch and the effect of UES botulinum toxin (botox) injections in these patients.
Methods: We prospectively enrolled consecutive patients with symptoms of inability to belch.
Background: Although nighttime reflux symptoms are common, the presence of nocturnal reflux is seldom confirmed with a standard 24 hours pH study.
Aim: To study patients with supine nighttime reflux symptoms using prolonged wireless pH monitoring.
Methods: In this retrospective study, patients with typical acid reflux symptoms were studied using 96-h pH monitoring.