Publications by authors named "J M Odell"
Gout flares after stopping anti-inflammatory prophylaxis: a rapid literature review and meta-analysis.
Arthritis Care Res (Hoboken)
December 2024
Objective: The aim of this research was to determine how common gout flares are after ceasing anti-inflammatory prophylaxis.
Methods: A rapid literature review and meta-analysis were undertaken. PubMed was searched from inception to February 2024.
Article Synopsis
- Urate-lowering treatment (ULT) using xanthine oxidase inhibitors (XOIs) initially increases gout flare-ups, and researchers aimed to understand inflammation responsiveness by analyzing blood samples from two independent trial cohorts over 48 weeks.
- The study found that after 48 weeks of ULT, serum urate levels normalized in patients and associated proteins indicated reduced inflammation and included key mediators of gout flare-ups, such as C5 and IL-1B.
- Mechanistic studies revealed that febuxostat treatment reduced proteins linked to complement activation in cultured macrophages, suggesting that monitoring serum proteins may help identify the decline of gouty inflammation in response to ULT.
Metastasis is the leading cause of cancer-related deaths, yet its regulatory mechanisms are not fully understood. Small-cell lung cancer (SCLC) is the most metastatic form of lung cancer, with most patients presenting with widespread disease, making it an ideal model for studying metastasis. However, the lack of suitable preclinical models has limited such studies.
View Article and Find Full Text PDFLamins are intermediate filament proteins that contribute to numerous cellular functions, including nuclear morphology and mechanical stability. The N-terminal head domain of lamin is critical for higher order filament assembly and function, yet the effects of commonly used N-terminal tags on lamin function remain largely unexplored. Here, we systematically studied the effect of two differently sized tags on Lamin A (LaA) function in a mammalian cell model engineered to allow for precise control of expression of tagged lamin proteins.
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