Publications by authors named "J M Ndiaye"
Article Synopsis
- * A study conducted in Senegal analyzed the genetic diversity of PfCyRPA in 95 malaria isolates, finding a mostly common wild type allele, with 15 identified single nucleotide polymorphisms (SNPs), mostly appearing as unique changes.
- * Structure-based modeling showed that while most SNPs have minor effects on PfCyRPA antibodies, some may significantly affect its structure or interaction with the viral protein PfRH5, providing insights for future malaria vaccine design.
Malaria is preventable, but the burden of disease remains high with over 249 million cases and 608,000 deaths reported in 2022. Historically, the most important protective interventions have been vector control and chemopreventive medicines with over 50 million children receiving seasonal malaria chemoprevention in the year 2023. Two vaccines are approved and starting to be deployed, bringing additional protection for children up to 36 months.
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- Epidemiological surveillance (ES) is crucial in the fight against malaria, particularly in Senegal's Tambacounda Health District, where it had been previously neglected.
- A survey of 27 health structures revealed that while the ES system was generally accepted by users, issues like low staff training and inadequate data analysis impacted its effectiveness, with only a 25.9% rate of data utilization among managers.
- The system demonstrated strong responsiveness and availability of management tools but requires improvements in staffing and training to enhance its stability and utility in controlling malaria-related morbidity and mortality.
Article Synopsis
- In Senegal, a study evaluated the effectiveness of mass drug administration (MDA) as a strategy to reduce malaria incidence, comparing it to the standard seasonal malaria chemoprevention (SMC) methods.
- The trial was conducted in 60 villages, with one group receiving MDA treatment and the other receiving SMC, both delivered door-to-door.
- Results showed MDA significantly reduced malaria cases by 55% during the peak transmission season, indicating it may be a more effective intervention than standard care without serious side effects reported.