Changes in optimism and subsequent health and wellbeing outcomes in older adults: an outcome-wide analysis.

Objectives: This study examined whether changes in optimism in older adulthood are associated with subsequent health and wellbeing outcomes.

Method: Longitudinal data are from the Health and Retirement Study, a nationally representative sample of U.S.

Persistent body-weight change on achalasia and peroral endoscopic myotomy: a multicenter cohort study.

Background: The distribution of body weight in patients with achalasia and after peroral endoscopic myotomy (POEM) has not been investigated. The role of body weight assessment after treatment remains unclear.

Methods: Using the multicenter achalasia cohort, the frequency of underweight (body mass index [BMI] < 18.

Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4-related amyloidosis.

With the aging of society, the incidence of chronic kidney disease (CKD), a common cause of death, has been increasing. Transcription factor EB (TFEB), the master transcriptional regulator of the autophagy-lysosomal pathway, is regarded as a promising candidate for preventing various age-related diseases. However, whether TFEB in the proximal tubules plays a significant role in elderly CKD patients remains unknown.

ERCP catheter or dilator? Which is best for fistula dilation following guidewire placement in EUS-guided transhepatic biliary drainage?

Objectives: EUS-guided biliary drainage (EUS-BD) is performed after endoscopic transpapillary biliary drainage fails. Although fistula dilation is one of the most difficult steps of EUS-BD, whether an ultratapered ERCP catheter or a dilator is the best choice for fistula dilation is unclear. In this study, we aimed to identify the optimal device for fistula dilation after guidewire placement.