Revascularization of smokers with claudication is not predicted to limit quality of life despite a higher risk of late failure.

Objective: Tobacco smoking after lower extremity revascularization for claudication has repeatedly been shown to increase the risk of adverse events, such that many vascular specialists consider that refusal to abstain from smoking constitutes a major contraindication to open surgical bypass or endovascular intervention.

Methods: A Markov decision analysis (DA) model was used to compare the options of direct revascularization vs medical therapy only in smokers with claudication. The primary outcome was calculated quality of life (cQoL), determined for each patient at follow-up based on the outcomes of the treatment received.

Needle-like morphology of H2K4b polyplexes associated with increases in transfection in vitro.

SUMMARY: Several synthetic histidine-lysine (HK) polymers have been screened for their efficacy as carriers of nucleic acids in vitro. One branched HK polymer, H2K4b (and its derivatives), has been particularly effective as an in vitro carrier of plasmids. In this study, we investigated whether various salt conditions during formation of the H2K4b/plasmid DNA polyplex affected transfection.

Oncogenes and tumor suppressor genes: therapeutic implications.

Genetic instability is a hallmark of cancer. Alterations in DNA through mutations, deletions, and translocations affect genes that are fundamental to normal cell growth differentiation and programmed cell death. Here, we discuss these alterations as they relate to oncogenes and tumor suppressor genes.

Dr. Peress and the downfall of Senator Joseph McCarthy.

McCarthy came down to Camp Kilmer, and to the Army's distress He uncovered a pink-tinted dentist, by the name of Irving Peress. That was the start of the struggle, that was the start of the strife And look at the uproar resulting; O take to the hills for your life!--Anonymous around the Pentagon, 1954.