Personalized whole-brain activity patterns predict human corticospinal tract activation in real-time.

Background: Transcranial magnetic stimulation (TMS) interventions could feasibly treat stroke-related motor impairments, but their effects are highly variable. Brain state-dependent TMS approaches are a promising solution to this problem, but inter-individual variation in lesion location and oscillatory dynamics can make translating them to the poststroke brain challenging. Personalized brain state-dependent approaches specifically designed to address these challenges are needed.

Variants in the AGBL5 gene are responsible for autosomal recessive Retinitis pigmentosa with hearing loss.

The AGBL5 gene encodes for the Cytoplasmic Carboxypeptidase 5 (CCP5), an α-tubulin deglutamylase that cleaves the γ-carboxyl-linked branching point of glutamylated tubulin. To date, pathogenic variants in AGBL5 have been associated only with isolated retinitis pigmentosa (RP). Hearing loss has not been reported in AGBL5-caused retinal disease.

Novel AIRTrode-based wearable electrode supports long-term, online brain-computer interface operations.

Non-invasive electroencephalograms (EEG)-based brain-computer interfaces (BCIs) play a crucial role in a diverse range of applications, including motor rehabilitation, assistive and communication technologies, holding potential promise to benefit users across various clinical spectrums. Effective integration of these applications into daily life requires systems that provide stable and reliable BCI control for extended periods. Our prior research introduced the AIRTrode, a self-adhesive (A), injectable (I), and room-temperature (RT) spontaneously-crosslinked hydrogel electrode (AIRTrode).

Large-scale molecular survey for piroplasmids in Iberian wild carnivores.

Piroplasmids are vector-borne hemoprotozoan parasites belonging to the phylum Apicomplexa that are of veterinary and medical importance. Wild carnivores are hosts for diverse piroplasmids, some of which are highly pathogenic for domestic dogs and cats. A large-scale survey including samples from 244 individuals belonging to eleven different species that were opportunistically obtained between 1993 and 2015 in four Autonomous Regions in Spain were tested for piroplasmid DNA with two different nested-PCR assays targeting the 18S rRNA gene.