Intratumoral Collagen Deposition Supports Angiogenesis Suggesting Anti-angiogenic Therapy in Armored and Cold Tumors.

A previous study classifies solid tumors based on collagen deposition and immune infiltration abundance, identifying a refractory subtype termed armored & cold tumors, characterized by elevated collagen deposition and diminished immune infiltration. Beyond its impact on immune infiltration, collagen deposition also influences tumor angiogenesis. This study systematically analyzes the association between immuno-collagenic subtypes and angiogenesis across diverse cancer types.

Posttreatment Blood Pressure as a Key Predictor in a 5-Year Stroke Prediction Model.

Evidence suggests that approximately 63.0%-84.2% of stroke survivors have hypertension, yet there is currently no stroke prediction tool specifically designed for individuals with hypertension.

High selectivity, capacity and stability for electrochemical lithium extraction on boron-doped HMnO by tailoring lattice constant and intercalation energy.

A sustainable supply of lithium from salt-lake brines is necessary due to the surge in demand of the lithium-battery market. However, the presence of coexisting ions, particularly Na, poses a significant challenge due to the similarities in charge, electronic structure, and hydrated size. The electrochemical system with manganese (Mn)-based lithium-ion (Li) sieves electrodes is a promising method for Li recovery, but often suffers from geometric configuration distortion, which reduces their selectivity and capacity.

Unveiling the role of microRNAs in nonhost resistance to Sclerotinia sclerotiorum: Rice-specific microRNAs attack the pathogen via cross-kingdom RNAi.

The development of rapeseed with high resistance against the pathogen Sclerotinia sclerotiorum is impeded by the lack of effective resistance resources within host species. Unraveling the molecular basis of nonhost resistance (NHR) holds substantial value for resistance improvement in crops. In the present study, small RNA sequencing and transcriptome sequencing were carried out between rice (a nonhost species of S.