Publications by authors named "J M McNicholl"
Assessing Non-Oral PrEP Alternatives Among Young Black Women in the Southern USA.
J Racial Ethn Health Disparities
January 2025
Young Black women in the southern US face a high HIV burden. While daily oral HIV pre-exposure prophylaxis (PrEP) can effectively prevent HIV, its use is low among Black women. The acceptability of and perceived intention to use emerging PrEP products among young Black women in the southern US are not well understood.
View Article and Find Full Text PDFIntroduction: It is widely acknowledged that good hand hygiene (HH) is an important non-pharmaceutical method for reducing the transmission of infectious diseases. Children are at high risk of infection due to their immature immune systems. Hospital transmitted infections are a cause for concern worldwide, with poor HH suggested to be responsible for up to 20% of cases.
View Article and Find Full Text PDFObjective: Sexually transmitted infections (STIs) increase mucosal HIV infection risk and have the potential to reduce preexposure prophylaxis efficacy. Clinical trials of a broadly neutralizing antibody (bNAb) provided proof-of-concept that passive immunization against HIV can be efficacious in people. We sought to evaluate preclinically the protective efficacy of passive bNAb immunization against simian-human immunodeficiency virus (SHIV) infection in the context of concurrent vaginal STIs.
View Article and Find Full Text PDFArticle Synopsis
- * A CDC report analyzed 57 hospitalized monkeypox patients from August to October 2022, revealing that 82% had HIV, most were male (95%), and 68% were non-Hispanic Black; 30% needed ICU care, and 21% died due to severe symptoms.
- * Health care providers are advised to test sexually active monkeypox patients for HIV and consider aggressive treatment for those who are severely immunocompromised
Article Synopsis
- The review highlights the importance of macaque models in testing preexposure prophylaxis (PrEP) for HIV, which helps in advancing both existing and new treatments.
- Recent developments in low-dose SHIV challenge models have led to more accurate simulations of HIV exposure in humans and have effectively predicted the efficacy of various approved PrEP strategies.
- These models are also being utilized to explore new PrEP options, while considering the effects of sexually transmitted infections on their effectiveness.