Publications by authors named "J M McKillop"
Article Synopsis
- In rural areas, atrial fibrillation (AF) management is primarily handled by local primary care providers, and there may be differing health outcomes for rural versus urban patients.
- A study analyzed data from the IMPACT-AF trial, comparing a clinical decision support system to standard care for AF management among 1133 patients, with 54.1% living in rural locations.
- Results showed rural patients had more referrals to general internists but fewer to cardiologists, and while there were no overall differences in emergency visits or hospitalizations, rural patients experienced higher rates of recurrent AF-related issues compared to urban patients.
Our earlier work showed that mammalian target of rapamycin (mTOR) is essential to the development of various hypertrophic responses, including cardiomyocyte survival. mTOR forms two independent complexes, mTORC1 and mTORC2, by associating with common and distinct cellular proteins. Both complexes are sensitive to a pharmacological inhibitor, torin1, although only mTORC1 is inhibited by rapamycin.
View Article and Find Full Text PDFPurpose: Oxidative stress has been implicated in Down syndrome (DS) pathology. This study compares DS individuals and controls on their urinary levels of allantoin and 2,3-dinor-iPF2α-III; these biomarkers have been previously validated in a clinical model of oxidative stress.
Methods: Urine samples were collected from 48 individuals with DS and 130 controls.