Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder: observational 6-month follow-up of a phase 2, double-blind, randomised, controlled trial.

Background: Psilocybin therapy (PT) produces rapid and persistent antidepressant effects in major depressive disorder (MDD). However, the long-term effects of PT have never been compared with gold-standard treatments for MDD such as pharmacotherapy or psychotherapy alone or in combination.

Methods: This is a 6-month follow-up study of a phase 2, double-blind, randomised, controlled trial involving patients with moderate-to-severe MDD.

Hyper-Expandable Cross-Linked Protein Crystals as Scaffolds for Catalytic Reactions.

Scaffolding catalytic reactions within porous materials is a powerful strategy to enhance the reaction rates of multicatalytic systems. However, it remains challenging to develop materials with high porosity, high diversity of functional groups within the pores, and guest-adaptive tunability. Furthermore, it is challenging to capture large catalysts such as enzymes within porous materials.

DNA-Directed Activation of Photocatalytic Labeling at Cell-Cell Contact Sites.

Cell-cell interactions govern diverse biological activities, necessitating molecular tools for understanding and regulating these interactions. Photoredox chemistry can detect cell-cell interactions by anchoring photocatalysts on cellular membranes to generate reactive species that tag closely contacting cells. However, the activation of photocatalysts lacks precise spatial resolution for selectively labeling intercellular interfaces.