Publications by authors named "J M Marin Lorente"
Lymph node metastasis (LNM) significantly affects the prognosis and clinical management of breast cancer (BC) patients. This systematic review and meta-analysis aim to identify microRNAs (miRNAs) associated with LNM in BC and evaluate their potential diagnostic and prognostic value. Following PRISMA guidelines, a comprehensive literature search was conducted in PubMed, Web of Science, and SCOPUS databases, to assess the role of miRNAs in LNM BC.
View Article and Find Full Text PDFIntraoperative goal-directed hemodynamic therapy targeting both arterial pressure and flow parameters using uncalibrated pulse contour techniques: A meta-analysis of randomized controlled trials.
Rev Esp Anestesiol Reanim (Engl Ed)
December 2024
Background: Goal-directed haemodynamic therapy (GDHT) aims to optimize haemodynamic variables. However, its effectiveness in reducing postoperative complications in major abdominal surgery, particularly when targeting both arterial pressure and flow variables, remains unclear. This meta-analysis addresses this by evaluating GDHT using uncalibrated pulse contour (uPC) methods.
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- Intimate partner violence (IPV) is a common form of abuse against women that leads to various health issues and involves physical, sexual, and emotional harm, as well as controlling behavior.
- This systematic review aims to explore the epigenetic changes linked to IPV and the stress resulting from it, following PRISMA 2020 guidelines and analyzing existing literature on the subject.
- Results indicate that IPV triggers significant epigenetic alterations in genes related to stress and health outcomes, impacting both victims and their children, highlighting the need for a better understanding of the biological effects of IPV.
Article Synopsis
- - The study explores how mu-opioid receptors (MORs) interact with neuroinflammation and glial cells, revealing a complex, bidirectional relationship rather than a straightforward immunosuppression effect.
- - Researchers found that activated microglia and certain proinflammatory cytokines boost neuronal MOR expression and enhance activation in response to the opioid DAMGO.
- - The results suggest a feedback loop where microglial activation and cytokine release influence neuronal MOR dynamics, indicating a need for further investigation into the implications for opioid use in pain management.
Resectable Non-Small Cell Lung Cancer Heterogeneity and Recurrence Assessed by Tissue Next-Generation Sequencing Genotyping and Circulating Tumor Cell EZH2 Characterization.
Arch Bronconeumol
October 2024
Introduction: Non-small cell lung cancer (NSCLC) is the most common type of lung neoplasm. Despite surgical resection, it has a high relapse rate, accounting for 30-55% of all cases. Next-generation sequencing (NGS) based on a customized gene panel and the analysis of circulating tumor cells (CTCs) can help identify heterogeneity, stratify high-risk patients, and guide treatment decisions.
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