Publications by authors named "J M M den Haan"
Purpose: Moderate hypofractionation was adopted to reduce hospital visits during the COVID-19 pandemic aiming to maintain treatment efficacy for soft tissue sarcoma (STS) patients, shifting preoperative schedules from 25 fractions of 2 Gy to 14-15 fractions of 3 Gy. This study evaluates the clinical implications and outcomes of this schedule, focusing on wound complications, radiation toxicity, local tumour control, and distant metastases.
Patients And Methods: Data was collected from patients treated between 01 and 01-2020 and 31-12-2023.
Proton radiotherapy significantly reduces pneumonia in oesophageal cancer patients.
Int J Radiat Oncol Biol Phys
January 2025
Background: Neoadjuvant chemoradiotherapy (nCRT) followed by surgical resection is the current standard of care for oesophageal cancer (EC) patients. This treatment is associated with a variety of complications, with pneumonia being the most common. We hypothesize that proton radiotherapy (PRT) can significantly reduce the incidence of pneumonia compared to photon radiotherapy (PhRT).
View Article and Find Full Text PDFArticle Synopsis
- The study focused on elderly patients (65+) with fall-related injuries who were also infected with COVID-19, analyzing their hospital outcomes.
- A total of 807 patients were reviewed, where 16% were tested for COVID-19, resulting in a 17% positivity rate among those tested, showcasing common comorbidities like hypertension and diabetes.
- The findings highlighted significant complications such as respiratory failure and a 19% in-hospital mortality rate, suggesting that COVID-19 poses a severe risk for older adults with fall injuries.
Introduction: The aim of this study was to assess the percentage of trauma patients admitted and receiving intervention, and to identify which of these interventions were performed by non-trauma specialists.
Methods: The authors conducted a retrospective chart review of all adult patients who presented to the trauma service between January 2019 and June 2019. Collected data included demographics, trauma activation level, total interventions performed, interventions performed by the trauma team, interventions performed by subspecialty teams, and isolated injuries requiring orthopedic, neurosurgical, or other specialized care.
With advances in long-read sequencing and assembly techniques, haplotype-resolved (phased) genome assemblies are becoming more common, also in the field of plant genomics. Computational tools to effectively explore these phased genomes, particularly for polyploid genomes, are currently limited. Here we describe a new strategy adopting a pangenome approach.
View Article and Find Full Text PDF