A search for violation of the charge-parity (CP) symmetry in the D^{+}→K^{-}K^{+}π^{+} decay is presented, with proton-proton collision data corresponding to an integrated luminosity of 5.4 fb^{-1}, collected at a center-of-mass energy of 13 TeV with the LHCb detector. A novel model-independent technique is used to compare the D^{+} and D^{-} phase-space distributions, with instrumental asymmetries subtracted using the D_{s}^{+}→K^{-}K^{+}π^{+} decay as a control channel.
View Article and Find Full Text PDFZoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild and 2 severe cases, including 1 death) detected in Paraná, Brazil, during 2020-2023. Genomes recovered were closely related to Brazilian swIAVs of three major lineages (1 A.
View Article and Find Full Text PDFTraditional testing methods in pharmaceutical development can be time-consuming and costly, but in silico evaluation tools can offer a solution. Our in-house Active-IT system, a Ligand-Based Virtual Screening (LBVS) tool, was developed to predict the biological and pharmacological activities of small organic molecules. It includes four independent modules for generating molecular descriptors (3D-Pharma), machine learning modeling (ExCVBA), a database of bioactivity models, and a prediction module.
View Article and Find Full Text PDFThis study addresses a critical gap in the existing literature on carbon dioxide and ionic liquid (IL) mixtures, where fragmented and incomplete data, particularly for flow properties, hinder practical applications. Therefore, this work aimed to establish a robust and efficient method for predicting the density of the CO-IL mixtures across diverse operating conditions and IL families using novel validation techniques. Both linear and symbolic regression models provided relevant insights but failed to accurately capture the IL-CO interactions in a mixture that determine the molar volume of CO at infinite dilution when solubilized by a given IL.
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