Publications by authors named "J M Logue"
Elucidating the relationships between a class I peptide antigen, a CD8 T cell receptor (TCR) specific to that antigen, and the T cell phenotype that emerges following antigen stimulation, remains a mostly unsolved problem, largely due to the lack of large data sets that can be mined to resolve such relationships. Here, we describe Antigen-TCR Pairing and Multiomic Analysis of T-cells (APMAT), an integrated experimental-computational framework designed for the high-throughput capture and analysis of CD8 T cells, with paired antigen, TCR sequence, and single-cell transcriptome. Starting with 951 putative antigens representing a comprehensive survey of the SARS-CoV-2 viral proteome, we utilize APMAT for the capture and single cell analysis of CD8 T cells from 62 HLA A*02:01 COVID-19 participants.
View Article and Find Full Text PDFArticle Synopsis
- * Patients reported improvements in physical functioning and fatigue within a year post-treatment, but indicators of pain, anxiety, and depression remained stable or worsened in those with active disease.
- * While overall toxicity decreased for the first 180 days, it increased again by day 360; prior therapies influenced worsening pain and anxiety in patients with extensive treatment histories.
Article Synopsis
- The study looks at how different groups of people in Seattle, based on their race, income, and gender, have different chances of getting paid sick leave (PSL).
- About 66.6% of the people surveyed had access to PSL, with higher rates among Asian and White respondents, while Black and low-income households had much lower access.
- It finds that having access to PSL is really important for everyone’s health, especially during situations like the COVID-19 pandemic, and suggests that better policies could help everyone stay healthier.
Background And Objective: The use and duration of androgen deprivation therapy (ADT) with postoperative radiotherapy (RT) have been uncertain. RADICALS-HD compared adding no ("None"), 6-months ("Short"), or 24-mo ("Long") ADT to study efficacy in the long term.
Methods: Participants with prostate cancer were indicated for postoperative RT and agreed randomisation between all durations.