Publications by authors named "J M Lobos Bejarano"
Background: Antimicrobial stewardship programs (ASPs) refer to a set of coordinated actions that improve the quality of care and combat antimicrobial resistance. Currently, information regarding the status of ASPs in Mexico is scarce. We aimed to describe the status of ASPs in 12 hospitals from Christus Muguerza Healthcare System.
View Article and Find Full Text PDFBackground: Candida auris, an emerging multidrug-resistant yeast, has become a global concern due to its association with nosocomial outbreaks and resistance to antifungal medications. The COVID-19 pandemic has exacerbated the situation, with several outbreaks reported worldwide, including in Mexico. We describe the clinical and microbiological characteristics of a multicentric outbreak in private institutions in Mexico.
View Article and Find Full Text PDFArticle Synopsis
- Genetic variation in the TMEM106B gene is linked to the risk and progression of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), with a specific genotype (rs3173615) associated with longer survival after symptoms begin.
- Research shows that the protective genotype is linked to lower accumulation of TMEM106B filaments, while the risk allele correlates with increased TMEM106B core deposition and enhanced TDP-43 dysfunction.
- The findings indicate that managing the accumulation of TMEM106B filaments may be a crucial factor in reducing disease risk and slowing down the progression of FTLD-TDP.
Background: Human papillomavirus (HPV) is the causative agent of nearly all forms of cervical cancer, which can arise upon viral integration into the host genome and concurrent loss of viral regulatory gene E2. Gene-based delivery approaches show that E2 reintroduction reduces proliferative capacity and promotes apoptosis in vitro.
Aims: This work explored if our calcium-dependent protein-based delivery system, TAT-CaM, could deliver functional E2 protein directly into cervical cancer cells to limit proliferative capacity and induce cell death.
Article Synopsis
- Phaeohyphomycosis is a serious infection caused by pigmented fungi, particularly affecting immunocompromised children, with a lower mortality rate compared to adults (22.3% in children vs. 79% in adults).
- A review of 130 pediatric cases showed common risk factors like hematologic malignancies, neutropenia, and steroid therapy, with localized infections being the most prevalent type (61.5%).
- Most cases were treated successfully with antifungal therapy (87%), but the mortality rate varied significantly based on the infection site and patient conditions, indicating a need for more research.