Publications by authors named "J M Leong"
In this work, we developed PolyMap (polyclonal mapping), a high-throughput method for mapping protein-protein interactions. We demonstrated the mapping of thousands of antigen-antibody interactions between diverse antibody libraries isolated from convalescent and vaccinated COVID-19 donors and a set of clinically relevant SARS-CoV-2 spike variants. We identified over 150 antibodies with a variety of distinctive binding patterns toward the antigen variants and found a broader binding profile, including targeting of the Omicron variant, in the antibody repertoires of more recent donors.
View Article and Find Full Text PDFEarly versus delayed timing of vitrectomy after open-globe injury.
Cochrane Database Syst Rev
November 2024
Article Synopsis
- This protocol outlines a Cochrane Review focused on the timing of vitrectomy following open-globe injuries.
- The main goal is to compare the effects of performing the surgery early versus later on patients' visual outcomes.
- The review aims to provide evidence that could guide clinical decisions regarding the optimal timing for vitrectomy in such cases.
Article Synopsis
- Mentoring is essential for professional identity formation (PIF), as it fosters personalized relationships and integrates program values, though its mechanisms remain unclear.
- A systematic scoping review examined existing literature on mentoring support from 2000 to mid-2023, using rigorous methodology to analyze themes and categories.
- Key findings highlight four domains vital to effective mentoring support: definitions and roles, personalisation, shepherding, and PIF, showcasing the importance of adapting mentoring approaches to meet individual mentee needs.
Parkinson's disease (PD) is an incurable, progressive and common movement disorder that is increasing in incidence globally because of population aging. We hypothesized that the landscape of rare, protein-altering variants could provide further insights into disease pathogenesis. Here we performed whole-exome sequencing followed by gene-based tests on 4,298 PD cases and 5,512 controls of Asian ancestry.
View Article and Find Full Text PDFArticle Synopsis
- Climate change may worsen sediment and salinity stresses in inshore turbid habitats, impacting coral fertilization and development.
- In experiments, the fertilization rate of Acropora tumida dropped by 50% under combined sediment and salinity stress, while Platygyra carnosa showed no significant impact.
- Abnormal embryonic development increased significantly for both species under stress, and A. tumida faced 50% larval mortality at a lower sediment concentration, raising concerns about coral survival in turbid environments.