Publications by authors named "J M Legler"
Article Synopsis
- The VHP4Safety project aims to create a Virtual Human Platform (VHP) that shifts safety assessments of chemicals and pharmaceuticals from animal testing to human-based methods, enhancing human health protection.
- The project involves collaboration among academic, regulatory, industrial, and societal partners and focuses on three main research areas: building the VHP, incorporating human data, and implementing the platform through real-world case studies.
- By combining innovative technology and stakeholder engagement through events like designathons, the project seeks to develop new methodologies for safety assessments while eliminating the need for animal testing.
Article Synopsis
- Micro- and nanoplastics (MNPs) are prevalent global pollutants with unknown health impacts, particularly concerning their ability to cross the placental barrier and affect reproductive health.
- The AURORA project aims to investigate the biological and health effects of MNP exposure during pregnancy and early life, focusing on enhancing measurement techniques for MNPs and related chemicals in human tissues.
- The project involves interdisciplinary methods, including observational studies of 800 mother-child pairs and toxicological assessments, to establish a framework for understanding the impact of MNPs on health and identify critical knowledge gaps.
Identification of Endocrine-Disrupting Chemicals (EDCs) in a regulatory context requires a high level of evidence. However, lines of evidence (e.g.
View Article and Find Full Text PDF: Metacarpal non-unions are complex hand defects that can lead to severe hand impairment. Treatment may require the use of artificial or autologous bone grafts. This systematic review aims to describe the outcomes of bone grafting following metacarpal non-union in an attempt to establish an optimal therapeutic protocol for this complication.
View Article and Find Full Text PDFPurpose: Anterior cruciate ligament (ACL) reconstruction is a common surgical procedure, yet failure still largely occurs due to nonanatomically positioned grafts. The purpose of this study was to retrospectively evaluate patients with torn ACLs before and after reconstruction via 3D MRI and thereby assess the accuracy of graft position on the femoral condyle.
Methods: Forty-one patients with unilateral ACL tears were recruited.