Gallatabenzene Ligands Emerging from Open Lutetocene and Yttrocene Methyl Complexes.

Utilizing ternary mixtures [LnMe]/K(2,4-dtbp)/GaMe (Ln=Lu, Y; 2,4-dtbp=2,4-di-tert-butyl-pentadienyl), a series of metallacycles is accessible via tandem salt metathesis/deprotonation. Depending on the precursor molar ratio, both gallatabenzene and lutetacyclic moieties with fully planar metallacycles are obtained, which were further analyzed using DFT calculations. The precursor molar ratio affects the extent of pentadienyl C-H-bond activation and oligomerization to tetra- and pentametallic arrays.

Continuous Right Ventricular Pressure Monitoring in Cardiac Surgery.

Objective: Right ventricular (RV) dysfunction in cardiac surgery can lead to RV failure, which is associated with increased morbidity and mortality. Abnormal RV function can be identified using RV pressure monitoring. The primary objective of the study is to determine the proportion of patients with abnormal RV early to end-diastole diastolic pressure gradient (RVDPG) and abnormal RV end-diastolic pressure (RVEDP) before initiation and after cardiopulmonary bypass (CPB) separation.

4S-fluorination of ProB29 in insulin lispro slows fibril formation.

Recombinant insulin is a life-saving therapeutic for millions of patients affected by diabetes mellitus. Standard mutagenesis has led to insulin variants with improved control of blood glucose; for instance, the fast-acting insulin lispro contains two point mutations that suppress dimer formation and expedite absorption. However, insulins undergo irreversible denaturation, a process accelerated for the insulin monomer.

Rare, Tightly-Bound, Multi-Cellular Clusters in the Pancreatic Ducts of Adult Mice Function Like Progenitor Cells and Survive and Proliferate After Acinar Cell Injury.

Pancreatic ductal progenitor cells have been proposed to contribute to adult tissue maintenance and regeneration after injury, but the identity of such ductal cells remains elusive. Here, from adult mice, we identify a near homogenous population of ductal progenitor-like clusters, with an average of 8 cells per cluster. They are a rare subpopulation, about 0.