Pembrolizumab in combination with binimetinib in patients with unresectable locally advanced or metastatic triple-negative breast cancer.

Purpose: Activation of the RAS/MAPK pathway is associated with reduced tumor-infiltrating lymphocytes and poor outcomes in triple-negative breast cancer (TNBC). Previous studies demonstrated that inhibition of the MAPK pathway with a MEK inhibitor is synergistic with immune checkpoint inhibitors.

Experimental Design: We conducted a phase I/II trial of pembrolizumab and binimetinib in patients with metastatic TNBC with ≤ 3 prior lines of therapy.

Effect of copper mill waste material on benthic invertebrates and zooplankton diversity and abundance.

Copper (Cu) stamp mill mining in North America from the early 1900s produced a pulverized ore by-product now known as stamp sands (SS). In a mining operation near the city of Gay (Michigan, USA), SS were originally deposited near a Lake Superior beach, but erosion and wave action have moved many SS into beaches and reefs that are critical spawning and nursery areas for native fish (e.g.

Outcomes Following a Mental Health Care Intervention for Children in the Emergency Department: A Nonrandomized Clinical Trial.

Importance: The emergency department (ED) is an important safety net for children experiencing mental and behavioral health crises and can serve as a navigational hub for families seeking support for these concerns.

Objectives: To evaluate the outcomes of a novel mental health care bundle on child well-being, satisfaction with care, and health system metrics.

Design, Setting, And Participants: Nonrandomized trial of 2 pediatric EDs in Alberta, Canada.

Readability of Patient Education Materials in Plastic Surgery: Assessing 14 Years of Progress.

Background: Current recommendations suggest that patient education materials (PEMs) be written at or below the sixth-grade reading level. In a 2010 study, the average readability of PEMs on the American Society of Plastic Surgeons (ASPS) and The Aesthetic Society (AS) websites was found to be at the 11th-grade level or higher. We sought to assess progress made toward providing accessible PEMs.

Persistent Metabolic Changes Are Induced by 24 h Low-Dose Lead (Pb) Exposure in Zebrafish Embryos.

Lead (Pb) is a heavy metal associated with a range of toxic effects. Relatively few studies attempt to understand the impact of lead on development from a mechanistic perspective. (zebrafish) embryos are a model organism for studying the developmental consequences of exposure to chemical agents.