Publications by authors named "J M L Williamson"
Background: In the Systolic Blood Pressure Intervention Trial (SPRINT), intensive systolic blood pressure (SBP) lowering slowed progression of white matter injury (WMI) on MRI. We hypothesized that intensive lowering would be equally as effective and may confer greater benefits for brain health at younger ages compared to older ages. We tested whether the relative effects of intensive lowering on WMI differed by age using 2 MRI measures: white matter hyperintensity volume (WMHv) and peak-width skeletonized mean diffusivity (PSMD) in SPRINT.
View Article and Find Full Text PDFBackground: As of 2024, an estimated 6.9 million individuals reside in the United States with Alzheimer's Disease (AD). Previous studies suggest that AD disproportionately affects females, who exhibit a higher incidence rate, poorer performance on various neuropsychological tasks, and more significant total brain atrophy.
View Article and Find Full Text PDFBackground: The Systolic Blood Pressure Intervention Trial (SPRINT) showed intensive blood pressure (BP) control, defined by systolic BP goal of < 120 mm Hg, reduced cardiovascular morbidity and mortality. However, a secondary analysis that incorporated approximately 4-years of observational follow-up found that mean BP levels increased after the trial and the benefit of intensive BP control on cardiovascular and all-cause mortality attenuated. We re-examined these findings using an updated version of the observational data that includes approximately 8-years of follow-up.
View Article and Find Full Text PDFBackground: For clinical trials or patient care, reports from a person familiar with the trajectory of a participant's cognitive and functional performance (i.e., proxies) may improve adjudication of events, such as mild cognitive impairment and dementia.
View Article and Find Full Text PDFBackground: Frailty may moderate efficacy of interventions for Alzheimer's disease (AD) and related dementias (ADRD), with higher efficacy at lower neuropathology burden in frailty. Using data from the Systolic Blood Pressure Intervention Trial (SPRINT) with extended post-trial follow-up, we assessed whether frailty moderated the effect of intensive blood pressure (BP) control and subsequent cognitive outcomes.
Methods: Primary outcomes were probable dementia (PD) and mild cognitive impairment (MCI).