Publications by authors named "J M Kratz"
Development and validation of ultra-performance liquid chromatography tandem mass spectrometry methods for the quantitative analysis of the antiparasitic drug DNDI-6148 in human plasma and various mouse biomatrices.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Article Synopsis
- * A validated ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method was developed to accurately measure DNDI-6148 levels in various biological samples, following international guidelines on bioanalytical methods.
- * The study found that collagenase A-based enzymatic homogenization extracted DNDI-6148 2.9 times more effectively from mouse skin compared to traditional methods, with consistent accuracy and recovery rates across different biomatrices
To optimize their fitness, cells face the crucial task of efficiently responding to various stresses. This necessitates striking a balance between conserving resources for survival and allocating resources for growth and division. The fundamental principles governing these tradeoffs is an outstanding challenge in the physics of living systems.
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- * Epidemiological studies indicate higher incidence rates of BTC in South and Central Asia, particularly for intrahepatic cholangiocarcinoma (iCCA), compared to much lower rates in Europe and the U.S.
- * The review also highlights the varying frequency of MDM2 gene amplifications in BTC subtypes, with gallbladder cancer showing the highest amplification rates, emphasizing the importance of standardized assessment in BTC research.
Article Synopsis
- Squamous cell carcinoma of the anus (SCCA) is becoming more common in the U.S., and while standard treatments have high toxicity, carboplatin and paclitaxel (C/P) combined with radiation may offer a safer alternative for patients who can't tolerate standard chemoradiation.
- In a study with ten patients (average age 75.5), 89% achieved a complete clinical response, and 67% remained alive without recurrence after a median follow-up of about 26 months.
- Common toxicities included leukopenia, anemia, and diarrhea, with severe side effects affecting a notable percentage, but overall, the C/P regimen showed good tolerability and effectiveness.